diff --git a/ChangeLog b/ChangeLog
index e4ca94b7b..1e89842e5 100644
--- a/ChangeLog
+++ b/ChangeLog
@@ -115,6 +115,8 @@ http://weechat.org/files/releasenotes/ReleaseNotes-devel.html[release notes]
 * python: fix load of scripts with python >= 3.3
 * relay: fix memory leak on unload of relay plugin
 * ruby: fix ruby init with ruby >= 2.0 (bug #41115)
+* scripts: fix script interpreter used after register during load of script
+  in python/perl/ruby/lua/guile plugins (bug #41345)
 * xfer: add support of IPv6 for DCC chat/file (patch #7992)
 * xfer: use same infolist for hook and signals (patch #7974)
 * xfer: add option xfer.file.auto_check_crc32 (patch #7963)
diff --git a/src/plugins/guile/weechat-guile-api.c b/src/plugins/guile/weechat-guile-api.c
index bdd47e92f..0f9e40be0 100644
--- a/src/plugins/guile/weechat-guile-api.c
+++ b/src/plugins/guile/weechat-guile-api.c
@@ -212,6 +212,7 @@ weechat_guile_api_register (SCM name, SCM author, SCM version, SCM license,
                             API_SCM_TO_STRING(version),
                             API_SCM_TO_STRING(description));
         }
+        guile_current_script->interpreter = scm_current_module ();
     }
     else
     {
diff --git a/src/plugins/guile/weechat-guile.c b/src/plugins/guile/weechat-guile.c
index d0f094284..26d61df11 100644
--- a/src/plugins/guile/weechat-guile.c
+++ b/src/plugins/guile/weechat-guile.c
@@ -425,7 +425,6 @@ weechat_guile_load (const char *filename)
     weechat_guile_catch (scm_gc_protect_object, (void *)module);
 
     guile_current_script = guile_registered_script;
-    guile_current_script->interpreter = (void *)module;
 
     /*
      * set input/close callbacks for buffers created by this script
diff --git a/src/plugins/lua/weechat-lua-api.c b/src/plugins/lua/weechat-lua-api.c
index d3e333de0..e54cbcbcf 100644
--- a/src/plugins/lua/weechat-lua-api.c
+++ b/src/plugins/lua/weechat-lua-api.c
@@ -156,6 +156,7 @@ weechat_lua_api_register (lua_State *L)
                                              "version %s (%s)"),
                             LUA_PLUGIN_NAME, name, version, description);
         }
+        lua_current_script->interpreter = (lua_State *) lua_current_interpreter;
     }
     else
     {
diff --git a/src/plugins/lua/weechat-lua.c b/src/plugins/lua/weechat-lua.c
index 8a4160a21..4a3a73ea4 100644
--- a/src/plugins/lua/weechat-lua.c
+++ b/src/plugins/lua/weechat-lua.c
@@ -445,8 +445,6 @@ weechat_lua_load (const char *filename)
     }
     lua_current_script = lua_registered_script;
 
-    lua_current_script->interpreter = (lua_State *) lua_current_interpreter;
-
     /*
      * set input/close callbacks for buffers created by this script
      * (to restore callbacks after upgrade)
diff --git a/src/plugins/perl/weechat-perl-api.c b/src/plugins/perl/weechat-perl-api.c
index 632e17872..6fb73f759 100644
--- a/src/plugins/perl/weechat-perl-api.c
+++ b/src/plugins/perl/weechat-perl-api.c
@@ -156,9 +156,6 @@ XS (XS_weechat_api_register)
                                              description, shutdown_func, charset);
     if (perl_current_script)
     {
-#ifndef MULTIPLICITY
-        perl_current_script->interpreter = SvPV_nolen (eval_pv ("__PACKAGE__", TRUE));
-#endif
         perl_registered_script = perl_current_script;
         if ((weechat_perl_plugin->debug >= 2) || !perl_quiet)
         {
@@ -167,6 +164,11 @@ XS (XS_weechat_api_register)
                                              "version %s (%s)"),
                             PERL_PLUGIN_NAME, name, version, description);
         }
+#ifdef MULTIPLICITY
+        perl_current_script->interpreter = perl_current_interpreter;
+#else
+        perl_current_script->interpreter = SvPV_nolen (eval_pv ("__PACKAGE__", TRUE));
+#endif
     }
     else
     {
diff --git a/src/plugins/perl/weechat-perl.c b/src/plugins/perl/weechat-perl.c
index d2b8f4a3c..e26d3de86 100644
--- a/src/plugins/perl/weechat-perl.c
+++ b/src/plugins/perl/weechat-perl.c
@@ -46,6 +46,9 @@ struct t_plugin_script *last_perl_script = NULL;
 struct t_plugin_script *perl_current_script = NULL;
 struct t_plugin_script *perl_registered_script = NULL;
 const char *perl_current_script_filename = NULL;
+#ifdef MULTIPLICITY
+PerlInterpreter *perl_current_interpreter = NULL;
+#endif
 int perl_quit_or_upgrade = 0;
 
 /*
@@ -345,10 +348,7 @@ weechat_perl_load (const char *filename)
     struct stat buf;
     char *perl_code;
     int length;
-
-#ifdef MULTIPLICITY
-    PerlInterpreter *perl_current_interpreter;
-#else
+#ifndef MULTIPLICITY
     char pkgname[64];
 #endif
 
@@ -454,9 +454,7 @@ weechat_perl_load (const char *filename)
     }
     perl_current_script = perl_registered_script;
 
-#ifdef MULTIPLICITY
-    perl_current_script->interpreter = (PerlInterpreter *)perl_current_interpreter;
-#else
+#ifndef MULTIPLICITY
     perl_current_script->interpreter = strdup (pkgname);
 #endif
 
diff --git a/src/plugins/perl/weechat-perl.h b/src/plugins/perl/weechat-perl.h
index c57a75f47..09f320c98 100644
--- a/src/plugins/perl/weechat-perl.h
+++ b/src/plugins/perl/weechat-perl.h
@@ -33,6 +33,9 @@ extern struct t_plugin_script *last_perl_script;
 extern struct t_plugin_script *perl_current_script;
 extern struct t_plugin_script *perl_registered_script;
 extern const char *perl_current_script_filename;
+#ifdef MULTIPLICITY
+extern PerlInterpreter *perl_current_interpreter;
+#endif
 
 extern HV *weechat_perl_hashtable_to_hash (struct t_hashtable *hashtable);
 extern struct t_hashtable *weechat_perl_hash_to_hashtable (SV *hash, int size,
diff --git a/src/plugins/python/weechat-python-api.c b/src/plugins/python/weechat-python-api.c
index 3a3cc7b68..0a8df4c6e 100644
--- a/src/plugins/python/weechat-python-api.c
+++ b/src/plugins/python/weechat-python-api.c
@@ -143,6 +143,7 @@ weechat_python_api_register (PyObject *self, PyObject *args)
                                              "version %s (%s)"),
                             PYTHON_PLUGIN_NAME, name, version, description);
         }
+        python_current_script->interpreter = (PyThreadState *)python_current_interpreter;
     }
     else
     {
diff --git a/src/plugins/python/weechat-python.c b/src/plugins/python/weechat-python.c
index cfd6117c8..b40f5d323 100644
--- a/src/plugins/python/weechat-python.c
+++ b/src/plugins/python/weechat-python.c
@@ -49,6 +49,7 @@ struct t_plugin_script *python_current_script = NULL;
 struct t_plugin_script *python_registered_script = NULL;
 const char *python_current_script_filename = NULL;
 PyThreadState *python_mainThreadState = NULL;
+PyThreadState *python_current_interpreter = NULL;
 char *python2_bin = NULL;
 
 /* outputs subroutines */
@@ -590,7 +591,6 @@ weechat_python_load (const char *filename)
     wchar_t *wargv[] = { NULL, NULL };
 #endif
     FILE *fp;
-    PyThreadState *python_current_interpreter;
     PyObject *weechat_outputs, *python_path, *path;
     const char *weechat_home;
     char *str_home;
@@ -754,7 +754,6 @@ weechat_python_load (const char *filename)
     }
     python_current_script = python_registered_script;
 
-    python_current_script->interpreter = (PyThreadState *) python_current_interpreter;
     /* PyEval_ReleaseThread (python_current_script->interpreter); */
 
     /*
diff --git a/src/plugins/python/weechat-python.h b/src/plugins/python/weechat-python.h
index 15c6f1e4d..b2b849629 100644
--- a/src/plugins/python/weechat-python.h
+++ b/src/plugins/python/weechat-python.h
@@ -42,6 +42,7 @@ extern struct t_plugin_script *last_python_script;
 extern struct t_plugin_script *python_current_script;
 extern struct t_plugin_script *python_registered_script;
 extern const char *python_current_script_filename;
+extern PyThreadState *python_current_interpreter;
 
 extern PyObject *weechat_python_hashtable_to_dict (struct t_hashtable *hashtable);
 extern struct t_hashtable *weechat_python_dict_to_hashtable (PyObject *dict,
diff --git a/src/plugins/ruby/weechat-ruby-api.c b/src/plugins/ruby/weechat-ruby-api.c
index 471f038a6..5408b8ffc 100644
--- a/src/plugins/ruby/weechat-ruby-api.c
+++ b/src/plugins/ruby/weechat-ruby-api.c
@@ -156,6 +156,7 @@ weechat_ruby_api_register (VALUE class, VALUE name, VALUE author,
                                              "version %s (%s)"),
                             RUBY_PLUGIN_NAME, c_name, c_version, c_description);
         }
+        ruby_current_script->interpreter = (VALUE *)ruby_current_module;
     }
     else
     {
diff --git a/src/plugins/ruby/weechat-ruby.c b/src/plugins/ruby/weechat-ruby.c
index 0b4ccd2f5..259786942 100644
--- a/src/plugins/ruby/weechat-ruby.c
+++ b/src/plugins/ruby/weechat-ruby.c
@@ -71,6 +71,7 @@ struct t_plugin_script *last_ruby_script = NULL;
 struct t_plugin_script *ruby_current_script = NULL;
 struct t_plugin_script *ruby_registered_script = NULL;
 const char *ruby_current_script_filename = NULL;
+VALUE ruby_current_module = NULL;
 
 /*
  * string used to execute action "install":
@@ -502,7 +503,7 @@ int
 weechat_ruby_load (const char *filename)
 {
     char modname[64];
-    VALUE curModule, ruby_retcode, err, argv[1];
+    VALUE ruby_retcode, err, argv[1];
     int ruby_error;
     struct stat buf;
 
@@ -527,12 +528,13 @@ weechat_ruby_load (const char *filename)
     snprintf (modname, sizeof(modname), "%s%d", MOD_NAME_PREFIX, ruby_num);
     ruby_num++;
 
-    curModule = rb_define_module(modname);
+    ruby_current_module = rb_define_module (modname);
 
     ruby_current_script_filename = filename;
 
     argv[0] = rb_str_new2 (filename);
-    ruby_retcode = rb_protect_funcall (curModule, rb_intern("load_eval_file"),
+    ruby_retcode = rb_protect_funcall (ruby_current_module,
+                                       rb_intern ("load_eval_file"),
                                        &ruby_error, 1, argv);
 
     if (ruby_retcode == Qnil)
@@ -572,13 +574,14 @@ weechat_ruby_load (const char *filename)
 
         if (NUM2INT(ruby_retcode) == 1 || NUM2INT(ruby_retcode) == 2)
         {
-            weechat_ruby_print_exception(rb_iv_get(curModule, "@load_eval_file_error"));
+            weechat_ruby_print_exception(rb_iv_get (ruby_current_module,
+                                                    "@load_eval_file_error"));
         }
 
         return 0;
     }
 
-    (void) rb_protect_funcall (curModule, rb_intern("weechat_init"),
+    (void) rb_protect_funcall (ruby_current_module, rb_intern ("weechat_init"),
                                &ruby_error, 0, NULL);
 
     if (ruby_error)
@@ -611,7 +614,6 @@ weechat_ruby_load (const char *filename)
     }
     ruby_current_script = ruby_registered_script;
 
-    ruby_current_script->interpreter = (VALUE *) curModule;
     rb_gc_register_address (ruby_current_script->interpreter);
 
     /*
diff --git a/src/plugins/ruby/weechat-ruby.h b/src/plugins/ruby/weechat-ruby.h
index 00b7d63b8..847cf2756 100644
--- a/src/plugins/ruby/weechat-ruby.h
+++ b/src/plugins/ruby/weechat-ruby.h
@@ -34,6 +34,7 @@ extern struct t_plugin_script *last_ruby_script;
 extern struct t_plugin_script *ruby_current_script;
 extern struct t_plugin_script *ruby_registered_script;
 extern const char *ruby_current_script_filename;
+extern VALUE ruby_current_module;
 
 extern VALUE weechat_ruby_hashtable_to_hash (struct t_hashtable *hashtable);
 extern struct t_hashtable *weechat_ruby_hash_to_hashtable (VALUE dict,